Human FSH Analyte Overview
Also known as Follicle Stimulating Hormone
Follicle-Stimulating Hormone (FSH) is a member of the glycoprotein hormone family secreted by the anterior pituitary gland. It is involved in the development and maintenance of the reproductive system, puberty, and reproduction. FSH activates the aromatase enzyme to convert androgen to estradiol, which ultimately regulates the formation of estrogen hormone. FSH works with Luteinizing Hormone (LH) to regulate female reproduction, particularly ovulation and follicular growth. Mutations of the FSH and FSHR (receptor) genes are linked to a reduction in reproduction function in females. In males, FSH supports spermatogenesis by activating Sertoli cells. Clinically, FSH is often measured to evaluate abnormal puberty timing, fertility issues, and pituitary function. Assisted reproductive treatments commonly uses recombinant FSH to induce follicle growth. Post-reproductive age, high levels of FSH increase the risk for bone loss due to osteoporosis.
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