Human GMCSF Analyte Overview
Also known as granulocyte macrophage colony stimulating factor, GM-CSF, colony-stimulating factor 2, CSF 2
Granulocyte-macrophage colony-stimulating factor (GM‑CSF), also known as colony-stimulating factor 2 (CSF2), is a growth factor that promotes the formation of white blood cells and is a critical component of the immune/inflammatory cascade. The growth factor is commonly used for in vitro colony formation of white blood cells. Numerous cell types produce GM-CSF in response to inflammation, particularly in the immune system, including T cells, B cells, macrophages, mast cells, endothelial cells, fibroblasts, and adipocytes. In hematopoietic cells, GM-CSF activates the functions of monocytes, macrophages, eosinophils, and granulocytes. In clinical settings, GM-CSF is capable of raising white blood cell counts in chemotherapy and bone marrow transplant patients and is being investigated as a potential cancer vaccination due to its ability to transfer targeted genetic material into tumor cells. Since GM-CSF initiates the development of an immune response, it is implicated in autoimmunity disorders and allergic inflammation. Patients with rheumatoid arthritis often have high levels of GM-CSF in their joints.
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