Human IL-33 Analyte Overview

Human IL-33

Also known as Interleukin 33

Interleukin 33 (IL-33) is an alarmin cytokine that signals through ST2 (IL-1R4/IL-1RL1). The IL-33/ST2 axis plays important roles in allergic inflammation as well as non-allergic inflammation. Targets of IL-33 include group 2 innate lymphoid cells, mast cells, regulatory T cells, Th2 cells, basophils, eosinophils, macrophages, dendritic cells, neutrophils, Th1 cells, CD8 T cells, natural killer cells, and invariant natural killer T cells. IL-33 is an alarmin cytokine often released upon tissue injury and tissue-derived immune cells constitutively express the ST2 receptor.  

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