Human IL-6R Analyte Overview
Also known as gp80, CD 126, IL6RQ, IL6Q, Interleukin-6 Receptor, Cluster of Differentiation 126 (CD126)
Interleukin 6 receptor (IL6R), also known as CD126, is a functional receptor for the IL-6 cytokine, that regulates many activities in the immune system, muscle tissue, and bone tissue. The receptor is commonly is expressed on hepatocytes, neutrophils, monocytes, B cells, and T cells, and in organs including muscle tissue, the heart, kidney, liver, spleen. placenta, lung, and brain. IL-6 and IL-6R have a low affinity for one another. High levels of IL-6R are often found in patients with early stage rheumatoid arthritis. Abnormal behavior of IL-6 and/or IL-6R is associated with chronic inflammatory conditions such as Crohn’s disease, multiple myeloma, and ulcerative colitis, as well as many cancers.
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