Human MMP-13 Analyte Overview
Also known as MMP-13, Matrix Metallopeptidase 13, Collagenase 3, CLG3, MANDP1, MDST
Matrix metalloproteinase 13 (MMP-13), also known as collagenase 3, is an enzyme that is involved with breaking down collagen. It is a member of the MMP family, a group of structural related zinc-dependent endopeptidases that are involved in breaking down different components of tissue. It is secreted by fibroblasts, chrondrocytes, and squamous epithelial cells as an inactive proprotein and is activated via processing with extracellular proteases. Though MMP13 is capable of breaking down collagen type I, II, and III, it is most efficient at degrading collagen type II. MMP13 is critical for normal bone formation during embryonic development, where it remodels the collagen matrix during mineralization. As with many members of the MMP family, high levels of MMP13 are associated with many kinds of cancer and arthritis. MMP13 is particularly implicated in osteoarthritis due to its role in cartilage remodeling. Aberrations in MMP13 expression are associated with developmental bone deformities.
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