Mouse CXCL-1 Analyte Overview
Also known as KC, GROα, Neutrophil-Activating Protein 3, NAP-3, Melanoma Growth Stimulating Activity
Mouse CXCL-1, also known as keratinocyte chemoattractant (KC) and GRO alpha, is a proinflammatory chemokine that plays a role in immune responses and many cancers. It is 64% sequence analogous to human GROα and performs similar functions in rodents. In the healthy immune system, CXCL-1 is produced by monocytes, epithelial cells, and fibroblasts in response to inflammatory activity. It induces neutrophil migration thought chemotaxis and has antimicrobial effects. It is also capable of promoting lymphatic tube and blood vessel formation within the circulatory system. In individuals with chronic inflammatory diseases, it is produced in high levels by many cell types. Abnormally high levels of CXCL-1 stimulate the growth of tumors and are particularly associated with melanomas due to its normal expression in epithelial cells. A frequent oncogenic culprit, it is often found up-regulated when tumor cells are present throughout the body.
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