Mouse GMCSF Analyte Overview
Also known as granulocyte macrophage colony stimulating factor, GM-CSF, colony-stimulating factor 2, CSF 2
Granulocyte-macrophage colony-stimulating factor (GM‑CSF), also known as colony-stimulating factor 2 (CSF2), is a growth factor that promotes the formation of white blood cells and is a critical component of the immune/inflammatory cascade. The growth factor is commonly used for in vitro colony formation of white blood cells. Numerous cell types produce GM-CSF in response to inflammation, particularly in the immune system, including T cells, B cells, macrophages, mast cells, endothelial cells, fibroblasts, and adipocytes. In hematopoietic cells, GM-CSF activates the functions of monocytes, macrophages, eosinophils, and granulocytes. In clinical settings, GM-CSF is capable of raising white blood cell counts in chemotherapy and bone marrow transplant patients and is being investigated as a potential cancer vaccination due to its ability to transfer targeted genetic material into tumor cells. Since GM-CSF initiates the development of an immune response, it is implicated in autoimmunity disorders and allergic inflammation. Patients with rheumatoid arthritis often have high levels of GM-CSF in their joints.
Assay Type: Sandwich
Sample Type: Serum
Assay Range: 2,000 – 2.74 pg/mL
Lower Limit of Detection (LLD): 2.30 pg/mL
Volume Required Per Well: Min. 25µL
Detection Method: Chemiluminescent
Singleplex Format: 96-well plate
Catalog #: 462249MS
Features & Requirements
- Measure GMCSF in 2.25 hours
- Sensitive, reproducible, and convenient 96-well format requiring low sample volumes
- Requires the Q-View™ Imaging System for analysis
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