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NHP IL-2Rα Analyte Overview

NHP IL-2Rα

Also known as CD25, IL-2 receptor alpha chain

Type I transmembrane protein primarily expressed by activated T cells, activated B cells, and regulatory T cells. It can also be detected on myeloid precursors, oligodendrocytes, and resting memory T cells (in humans). IL-2Rα, IL-2Rβ, and the common gamma chain make up the high-affinity IL-2 receptor while a homodimer of the IL-2Rα chain makes up the low-affinity IL-2 receptor. It is important for detecting signal from IL-2 for growth signals, generating immunity, and maintaining immune tolerance.

IL-2Rα can also be found in a soluble form, resulting from extracellular proteolysis. Soluble IL-2Rα may play a role as a decoy receptor that reduces bioavailability of IL-2 or it may promote in trans activation by presenting IL-2 to dimeric IL-2 receptor expressing cells.

Typical Assay Characteristics

NHP IL-2Ra graph image
Precision Linearity
Inter-assay Intra-assay Range Average
13% 12% 85%-136% 111%

Q-Plex™ Details

Species: NHP
Assay Type: Sandwich
Sample Type: Serum/Plasma, Cell Supernatant
Assay Range: 16,000 – 21.95 pg/mL
Lower Limit of Detection (LLD): 10.97 pg/mL
Volume Required Per Well: Min. 25µL
Detection Method: Chemiluminescent
Singleplex Format: 96-well plate

Features & Requirements

  • Data available as fast as 4 hours
  • Sensitive, reproducible, and convenient 96-well format requiring low sample volumes
  • Requires the Q-View™ Imaging System for analysis of multiplexed chemiluminescent planar-based arrays

Featured Q-Plex Products

Q-Plex™ NHP Anti-Inflammatory Panel 1 (7-Plex)

IL-1RA, IL-2Rα, IL-4, sIL-6R, IL-10, IL-13, TNFRII

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