NHP IP-10 Analyte Overview


Also known as Interferon Gamma-Induced Protein 10, CXCL10, C-X-C Motif Chemokine 10

Interferon gamma-induced protein 10 (IP-10), also known as C-X-C motif chemokine 10 (CXCL10) or small-inducible cytokine B10, is a small cytokine with diverse roles in the immune system. Many cell types release IP-10 in response to stimulation from IFN-γ. It has chemotactic properties for activated T cells, monocytes, macrophages, natural killer cells, and dendritic cells. It promotes the adhesion of T cells to endothelial cells and has strong anti-tumor properties. It inhibits bone marrow colony formation and angiogenesis. IP-10 expression has been associated with HIV-1 infection, where it contributes to the accumulation of activated T cells in the cerebrospinal fluid compartment of infected individuals. The retroviral transactivator, HIV-1 Tat, is a potent inducer of IP-10 expression in astrocytes. IP-10 expression has also been shown to be significantly elevated in astrocytes within the brains of Alzheimer’s disease patients, where its expression is associated with senile plaques. Higher levels of IP-10 are documented in Hepatitis C patients who respond poorly to antiviral treatment.

Typical Assay Characteristics

NHP IP-10 analyte graph
Precision Linearity
Inter-assay Intra-assay Range Average
20% 4% 73%-121% 93%

Q-Plex™ Details

Species: NHP
Assay Type: Sandwich
Sample Type: Serum/Plasma, Cell Supernatant
Assay Range: 2,984 – 4.09 pg/mL
Lower Limit of Detection (LLD): 2.05 pg/mL
Volume Required Per Well: Min. 25µL
Detection Method: Chemiluminescent
Singleplex Format: 96-well plate

Features & Requirements

  • Data available as fast as 4 hours
  • Sensitive, reproducible, and convenient 96-well format requiring low sample volumes
  • Requires the Q-View™ Imaging System for analysis of multiplexed chemiluminescent planar-based arrays

Featured Q-Plex Products

Q-Plex™ NHP Chemokine Screen (9-Plex)

CXCL-1, IL-8, IP-10, MCP-1, MIF, MIG, MIP-1α, MIP-1ß, RANTES

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