NHP IP-10 Analyte Overview
Also known as Interferon Gamma-Induced Protein 10, CXCL10, C-X-C Motif Chemokine 10
Interferon gamma-induced protein 10 (IP-10), also known as C-X-C motif chemokine 10 (CXCL10) or small-inducible cytokine B10, is a small cytokine with diverse roles in the immune system. Many cell types release IP-10 in response to stimulation from IFN-γ. It has chemotactic properties for activated T cells, monocytes, macrophages, natural killer cells, and dendritic cells. It promotes the adhesion of T cells to endothelial cells and has strong anti-tumor properties. It inhibits bone marrow colony formation and angiogenesis. IP-10 expression has been associated with HIV-1 infection, where it contributes to the accumulation of activated T cells in the cerebrospinal fluid compartment of infected individuals. The retroviral transactivator, HIV-1 Tat, is a potent inducer of IP-10 expression in astrocytes. IP-10 expression has also been shown to be significantly elevated in astrocytes within the brains of Alzheimer’s disease patients, where its expression is associated with senile plaques. Higher levels of IP-10 are documented in Hepatitis C patients who respond poorly to antiviral treatment.
Typical Assay Characteristics
Not Finding What You Need?
Customize a Kit
Not seeing the biomarker or analyte you need? Customize your kit! The Q-Plex™ Custom Assays are fully quantitative ELISA-based Chemiluminescent assay kits allowing the concurrent measurement of up to 18 biomarkers or analytes.
Send in Your Samples
Choose up to 18 different biomarkers that will work best for your research. Send in your samples and let us run them for you.
Contact a Representative
Have questions about the kit or interested in more information? Contact one of our representative to get all your questions answered.