NHP MCP-1 Analyte Overview
Also known as Monocyte Chemotactic Protein 1, Chemokine Ligand 2, CCL2, Small Inducible Cytokine A2, SCYA2
Monocyte chemoattractant protein 1 (MCP1), also known as chemokine (C-C motif) ligand 2 (CCL2) and small inducible cytokine (A2MCP-1), is a chemokine that plays a role in the body’s response to tissue injury and infection. It is produced by many cell types in response to tissue damage, and is a chemoattractant to monocytes, basophils, memory T cells, and dendritic cells. MCP-1 is commonly found at the site of tooth and bone injuries or infections, where it is expressed by osteoclasts and osteoblasts. It is also produced by cells of the nervous system and is implicated in many inflammatory neurological disorders. Elevated MCP-1 levels are often associated with sepsis, Crohn’s disease, lupus nephritis, amyotrophic lateral sclerosis, multiple sclerosis, rheumatoid arthritis, acute pancreatitis, and atherosclerosis. MCP-1 is also upregulated in several cancers including gastric carcinoma, esophageal squamous cell carcinoma, malignant glioma, and ovarian, pancreatic, bladder, and breast cancers.
Typical Assay Characteristics
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