NHP MIP-1α Analyte Overview
Also known as MIP-1α, Macrophage Inflammatory Protein-1 alpha, Chemokine Ligand 3, CCL3
Macrophage inflammatory protein 1-alpha (MIP-1α), also known as chemokine (C-C motif) ligand 3 (CCL3), is a cytokine of the immune system involved in inflammation and fever. MIP-1α and its counterpart MIP-1β are produced primarily by macrophages following exposure to a bacterial endotoxin but can also be secreted by other immune cells. It works to activate granulocyte white blood cells and stimulate the production of other pro-inflammatory cytokines. Its presence also limits the production of hematopoietic stem cells. MIP-1α has the ability to induce a rapid onset fever in response to an infection. MIP-1α is capable of suppressing HIV infection since it binds to CCR5, a common HIV coreceptor. MIP-1α is implicated in many diseases, including multiple myeloma, cystic fibrosis, and breast cancer.
Typical Assay Characteristics
Features & Requirements
- Data available as fast as 4 hours
- Sensitive, reproducible, and convenient 96-well format requiring low sample volumes
- Requires the Q-View™ Imaging System for analysis of multiplexed chemiluminescent planar-based arrays
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