NHP RANTES Analyte Overview
Also known as regulated on activation normal T cell expressed and secreted cysteine-rich protein, CCL5, XCP1
Regulated on activation, normal T cell expressed and secreted (RANTES), also known as Chemokine (C-C motif) ligand 5 (CCL5) is a cytokine that mediates inflammatory response of the immune system. It is chemotactic to T lymphocytes, basophils, and eosinophils. RANTES activates and increases the cytotoxicity and proliferation of natural killer cells. It is secreted by fibroblasts, platelets, and T cells at the site of inflammation. RANTES is also involved in the progression and metastasis of some malignant tumors where it may promote migration of cancer cells. Its expression is upregulated in the white adipose tissue of obese individuals and may be involved in obesity related inflammation. RANTES is strongly HIV suppressive, preventing replication of certain HIV strains and is currently under investigation as a therapeutic for the virus.
Typical Assay Characteristics
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