NHP sIL-1RA Analyte Overview


Also known as IL-1Ra, IL-1F3, Interleukin-1 Receptor Antagonist

Interleukin 1 receptor antagonist (IL-1Ra) is an acute phase protein that is a member of the Interleukin 1 family of cytokines. It blocks Interleukin 1 alpha and beta (IL-1α and IL-1β) from binding to the Interleukin 1 receptor type 1. The IL-1 family plays an important role in both adaptive and innate immunity through promoting inflammation, IL-1Ra works to reduce inflammation and fever responses. It is secreted by a variety of cell types, including immune cells, epithelial cells, and adipocytes. It is commonly used in veterinary medicine to calm inflamed soft tissue injuries. A modified version is used in human medicine to treat rheumatoid arthritis. Aberrations in IL-1Ra are associated with schizophrenia and are commonly found in high levels in schizophrenia patients.

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