NHP TIMP-2 Analyte Overview
NHP TIMP-2
Also known as Tissue inhibitor of metalloproteinases 2
Tissue inhibitor of metalloproteinases 2 (TIMP2) is a glycoprotein in the TIMP family of proteins, which regulate the activity of matrix metalloproteinases. Metalloproteinases degrade the extracellular matrix. As an inhibitor of metalloproteinases, TIMP2 minimizes matrix digestion by these enzymes and is most effective at inhibiting MMP2. TIMP2 also has the unique ability to repress the proliferation of endothelial cells. It may be critical to tissue homeostasis, preventing the overgrowth of certain cell types during blood vessel formation and limiting MMP2 activity in the extracellular matrix of tissues during remodeling. TIMP2 is critical to normal hippocampal behavior and supports cognitive function. It may suppress certain cancers by preventing cell proliferation during angiogenesis.
Typical Assay Characteristics
Precision | Linearity | ||
---|---|---|---|
Inter-assay | Intra-assay | Range | Average |
10% | 7% | 71%-132% | 107% |
Q-Plex™ Details
Species: NHP
Assay Type: Sandwich
Sample Type: Serum/Plasma, Cell Supernatant
Assay Range: 20,000 – 27.43 pg/mL
Lower Limit of Detection (LLD): 13.72 pg/mL
Volume Required Per Well: Min. 25µL
Detection Method: Chemiluminescent
Singleplex Format: 96-well plate
Features & Requirements
- Data available as fast as 4 hours
- Sensitive, reproducible, and convenient 96-well format requiring low sample volumes
- Requires the Q-View™ Imaging System for analysis of multiplexed chemiluminescent planar-based arrays
Featured Q-Plex Products
Build a Custom Kit with This Analyte
Current retail kits are unavailable but you can create a custom kit using this specific analyte and any others you may need.
Not Finding What You Need?
Customize a Kit
Not seeing the biomarker or analyte you need? Customize your kit! The Q-Plex™ Custom Assays are fully quantitative ELISA-based Chemiluminescent assay kits allowing the concurrent measurement of up to 18 biomarkers or analytes.
Send in Your Samples
Choose up to 18 different biomarkers that will work best for your research. Send in your samples and let us run them for you.
Contact a Representative
Have questions about the kit or interested in more information? Contact one of our representative to get all your questions answered.
As researchers and problem solvers ourselves, we understand the value of sound data. We are proud to be a part of research that can better the world. We value the relationships, partnerships, and friendships that we have built with the people who trust and use our technology. We are committed to building these relationships. You can count on us to answer the phone and take time to thoroughly address questions or concerns about any of our products. In an industry that is reputed for grandiose claims, we trust that our quality standards and our customer service set us apart from the competition. If you’re happy with our products or if you think we can do something better, we hope you will let us know.