NHP VEGF Analyte Overview
NHP VEGF
Also known as Vascular Endothelial Growth Factor, Vascular Permeability Factor, VPF
Vascular endothelial growth factor (VEGF), also known as vascular permeability factor (VPF), is a family of growth factors that stimulate the formation of new blood vessels. VEGF is critical for vascular development during embryonic growth and supports angiogenesis for wound repair, supporting exercise, and bypassing blocked vessels in adults. The production of VEGF is stimulated by lack of oxygen in a cell, encouraging the production of blood vessels to supply tissues with oxygen and nutrients. VEGF concentrations raise rapidly following injury to support angiogenesis to repair the wound. Abnormal expression of VEGF is implicated in multiple diseases, including rheumatoid arthritis, diabetic retinopathy, age-related macular degeneration, pulmonary emphysema, protein accumulation in the kidneys, and early-onset pre-eclampsia. Tumors that express VEGF are able to vascularize and grow much larger than those that do not and the factor appears to support metastasis, though the exact mechanism is unknown. High levels of VEGF are associated with poor prognosis in cancer patients.
Typical Assay Characteristics
| Precision | Linearity | ||
|---|---|---|---|
| Inter-assay | Intra-assay | Range | Average |
| 8% | 6% | 62%-115% | 81% |
Features & Requirements
- Data available as fast as 4 hours
- Sensitive, reproducible, and convenient 96-well format requiring low sample volumes
- Requires the Q-View™ Imaging System for analysis of multiplexed chemiluminescent planar-based arrays
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