Q-Plex™ Human Chemokine (4-Plex)
Q-Plex™ Product Overview
The Q-Plex Human Chemokine (4-Plex) is a fully quantitative ELISA-based chemiluminescent assay allowing concurrent measurement of four biomarkers or analytes (IL-8, IP-10, MCP-1, Rantes).
Each kit contains a 96-well plate, with each well featuring the relevant biomarker panel, and all the reagents required to perform testing. Q-Plex plates are built by absorbing four distinct capture antibodies in a defined array to the bottom of each well. Our high-quality reagents help ensure the accuracy of your results.
Using only 25 µl of sample per well, up to 80 samples can be assayed for all four markers in the panel in 2.25 hours. Q-Plex™ Arrays provide scientists with an easy-to-use and cost-effective means of generating a cytokine profile for each sample.
Q-Plex Human Chemokine (4-Plex)
For measurement of IL-8, IP-10, MCP-1, Rantes
Interleukin 8 (IL-8), also known as CXCL8, is a chemokine that plays a role in the recruitment and regulation of white blood cells during an innate immune response. It is a strong chemoattractant for neutrophils and other granulocytes, bringing them to the site of infection and then stimulating them to engage in phagocytosis. It is commonly secreted by macrophages that have identified a foreign pathogen but may be emitted by any cell with toll-like receptors. IL-8 plays a key role in metastasis; it was first identified as a leukocyte chemoattractant that progresses melanoma by directly inducing angiogenesis and migration of melanoma cells. Serum IL-8 levels are directly correlated with the degree of metastatic melanoma and overall tumor count. High levels of IL-8 in a pregnant mother are associated with schizophrenia in her child and high levels in adults with schizophrenia reduces the effectiveness of antipsychotic medications. IL-8 dysregulation is also involved in cystic fibrosis, where it recruits an excessive number of white blood cells to the lungs, resulting in tissue damage.
Each kit contains a 96-well plate, featuring the relevant biomarker panel in each well, and all reagents required to perform testing.
- Detection Mix
- Sample Diluents
- Streptavidin HRP
- Wash Buffer
Q-Plex™ arrays are developed and optimized to work with Q-View™ imagers. Quansys does not guarantee the results obtained from other imagers and not all imagers are compatible with Quansys Q-Plex arrays.