Human CD-14 Analyte Overview
Also known as CD14, Monocyte differentiation antigen CD14, Myeloid cell-specific leucine-rich glycoprotein, Cluster of differentiation 14
CD-14 is an acute phase glycoprotein that operates as a component of the innate immune system, where it is expressed primarily in the cell membranes of macrophages and neutrophils. It detects bacterial lipopolysaccharide, a component of the outer membrane of gram-negative bacteria. In the presence of lipopolysaccharide-binding protein, CD-14 binds with bacterial membranes to initiate a cascade response with TLR4 that triggers the activation of an inflammatory response. CD-14 may be either anchored to cell membranes or take a soluble form when excreted by liver cells and monocytes. Soluble CD-14 has the ability to confer the bacterial lipopolysaccharide response to cells that do not natively express CD-14 in their membranes and is found in human breastmilk, where it may act as a regulator of microbial growth in the infant gut.
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