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Q-Plex™ Human Environmental Enteric Dysfunction (11-Plex)

Q-Plex Human Environmental Enteric Dysfunction (11-Plex)

For measurement of ferritin, thyroglobulin, sTfR, HRP2, IGF-1, FGF-21, IFABP, CRP, CD-14, AGP, RBP4

  • Species Reactivity: Human
  • Validated Sample Type: Serum, Heparin Plasma
  • Sample Volume Required: 5 µL
  • Estimated Assay Length: 3.5 hours
  • Cross-Reactivity and Interference: No significant interference observed. <1% cross-reactivity observed. 
  • Assay Type: Varies (See Performance and Validation Data table below)
  • Detection Method: Chemiluminescent
  • Multiplex Format: 96-well solid plate
  • Catalog No: #569849HU
Analytes Assay Type Calibrator Range Upper Limit of Quantification (ULOQ) Lower Limit of Quantification (LLOQ) Limit of Detection Precision*
(Inter-assay)
Precision*
(Intra-assay)
Linearity
Ferritin Sandwich 115 - 0.16 (μg/L) 99 (µg/L) 0.14 (µg/L) 0.2057 (µg/L) 12% 4% 85-110% (103%)
Thyroglobulin Sandwich 13.7 - 0.019 (μg/L) 12 (µg/L) 0.02 (µg/L) 0.0244 (µg/L) 13% 4% 95-110%
(103%)
sTfR Sandwich 107.525 - 0.15 (mg/L) 104 (mg/L) 0.14 (mg/L) 0.1917 (mg/L) 15% 6% 95-111%
(101%)
HRP2 Sandwich 0.955 - 0.0013 (μg/L) 0.85 (µg/L) 0.0012 (µg/L) 0.0017 (µg/L) 13% 6% 83-117%
(106%)
IGF-1 Sandwich 198 - 0.27 (ng/mL) 186 (ng/mL) 0.26 (ng/mL) 0.27 (ng/mL) 13% 7% 100-131%
(117%)
FGF-21 Sandwich 800 - 0.11 (pg/mL) 1800 (pg/mL) 2.47 (pg/mL) 1.1 (pg/mL) 12% 4% 96-104%
(101%)
IFABP Sandwich 3000 - 4.1 (pg/mL) 2800 (pg/mL) 3.84 (pg/mL) 4.12 (pg/mL) 10% 6% 87-108%
(97%)
CRP Competitive 5.61 - 0.008 (mg/L) 21 (mg/L) 0.0288 (mg/L) 0.1112 (mg/L) 14% 3% 91-111%
(99%)
CD-14 Competitive 1750 - 2.4 (ng/mL) 1750 (ng/mL) 2.40 (ng/mL) 2.4 (ng/mL) 11% 4% 85-104%
(93%)
AGP Competitive 0.36 - 0.0015 (g/L) 0.42 (g/L) 0.0006 (g/L) 0.0019 (g/L) 12% 5% 100-114%
(108%)
RBP4 Competitive 1.4 - 0.006 (μmol/L) 1.9 (μmol/L) 0.0026 (μmol/L) 0.0054 (μmol/L) 11% 6% 81-101%
(94%)

Product Overview

Environmental Enteric Dysfunction (EED) is characterized by inflammation at mucosal sites, reduced intestinal barrier integrity, and poor absorption of nutrients. EED is common among people living in low-resource settings with high enteric-pathogen prevalence and poor sanitation. Complications related to EED include stunted growth, reduced responsiveness to vaccines, and impaired cognitive development. Children are therefore especially at risk as these severe complications increase susceptibility to other childhood diseases such as pneumonia, acute diarrhea, and malaria. 

Developed in collaboration with PATH, the Q-Plex Human Environmental Enteric Dysfunction (11-Plex) was designed to be a tool to help with identifying people with EED at high risk for additional complications. The array provides researchers an easy-to-use and cost-effective means of generating a profile of nutritional and inflammatory biomarkers for each sample. 

Kit Content

Each kit contains a 96-well plate, featuring the relevant biomarker panel in each well, and all reagents required to perform testing.

Reagents Include:

  • Calibrator
  • Competitor
  • Detection Mix
  • Substrate
  • Sample Diluents
  • Streptavidin HRP
  • Wash Buffer

Publications

Processing

All Quansys Q-Plex™ Multiplex and Singleplex assays require the use of the Q-View™ software to read and interpret the test results. A fully-functional, free trial version of the software is available to download, install, and use to analyze your first kit(s). At the end of the trial period, a purchased license is required to continue the use of the Q-View software.

Q-Plex™ arrays are developed and optimized to work with Q-View™ imagers. Quansys does not guarantee the results obtained from other imagers and not all imagers are compatible with Quansys Q-Plex arrays.

Other Equipment Recommendations

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    As researchers and problem solvers ourselves, we understand the value of sound data. We are proud to be a part of research that can better the world. We value the relationships, partnerships, and friendships that we have built with the people who trust and use our technology. We are committed to building these relationships. You can count on us to answer the phone and take time to thoroughly address questions or concerns about any of our products. In an industry that is reputed for grandiose claims, we trust that our quality standards and our customer service set us apart from the competition. If you’re happy with our products or if you think we can do something better, we hope you will let us know.

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