Human CRP Analyte Overview
Also known as CRP, C-Reactive protein, PTX1, MGC149895, MGC88244
C-Reactive Protein (CRP) is a pentameric protein that functions as a sensor and activator for the innate immune system. It is secreted by the liver in response to immune factors released by macrophages and T cells, and rises in association with an inflammatory response. CRP binds to the surface of apoptotic cells and bacteria to activate the compliment system, which induces the phagocystosis and removal of dead or foreign cells. It also promotes dendritic cell maturation and humoral immunity. CRP is commonly measured as a marker of systemic inflammation. High levels are associated with cardiovascular disease, cancer, sleep apnea, and inflammatory diseases such as Crohn’s disease and inflammatory bowel disease (IBD). In cardiovascular disease, excess CRP binds to oxidized LDL cholesterol, exacerbates tissue damage in myocardial infarction, and inhibits the repair of injured vascular endothelium.
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