Human TIMP-1 Analyte Overview
Also known as Tissue Inhibitors of Metalloproteinases 1, Erythroid Potentiating Activity, EPA, Human Collagenase Inhibitor, HCI
Tissue inhibitor of metalloproteinases 1 (TIMP1) is a glycoprotein in the TIMP family of proteins, which regulate the activity of matrix metalloproteinases. Metalloproteinases degrade the extracellular matrix. As an inhibitor of metalloproteinases, TIMP-1 minimizes matrix digestion by these enzymes and is most effective at inhibiting MMP1, MMP7, and MMP9. It is produced by a wide range of cell types and likely helps to maintain tissue homeostasis by preventing tissue degradation. It is important for maintaining the extracellular matrix and supporting wound healing. TIMP1 also plays a critical role in pregnancy, facilitating implantation of the egg onto the uterine wall and regulating early transcription in the developing embryo. High levels of TIMP1 are associated with poor prognosis in cancer patients.
Assay Performance Characteristics
Average Intra-assay CV: 8%
Average Inter-assay CV: 12%
|Dilution Factor||% Recovery|
|Stripped Serum||Cell Culture Supernatant||Sample 3||Sample 4|
|2||82%||106%||Not Detectable||Not Detectable|
Average percent linearity: 98%
Percent linearity range: 91 – 104%
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