Human TIMP-2 Analyte Overview

Human TIMP-2

Also known as Tissue inhibitor of metalloproteinases 2

Tissue inhibitor of metalloproteinases 2 (TIMP2) is a glycoprotein in the TIMP family of proteins, which regulate the activity of matrix metalloproteinases. Metalloproteinases degrade the extracellular matrix. As an inhibitor of metalloproteinases, TIMP2 minimizes matrix digestion by these enzymes and is most effective at inhibiting MMP2. TIMP2 also has the unique ability to repress the proliferation of endothelial cells. It may be critical to tissue homeostasis, preventing the overgrowth of certain cell types during blood vessel formation and limiting MMP2 activity in the extracellular matrix of tissues during remodeling. TIMP2 is critical to normal hippocampal behavior and supports cognitive function. It may suppress certain cancers by preventing cell proliferation during angiogenesis.

Q-Plex™ Details

Species: Human
Assay Type: Sandwich
Sample Type: Human Serum, EDTA Plasma
Assay Range: 20,000 – 27.40 pg/mL
Lower Limit of Detection (LLD): 15.90 pg/mL
Volume Required Per Well: Min. 25µL
Detection Method: Chemiluminescent
Singleplex Format: 96-well plate
Catalog #: 469649HU

Features & Requirements

  • Measure TIMP-2 in 2.25 hours
  • Sensitive, reproducible, and convenient 96-well format requiring low sample volumes
  • Requires the Q-View™ Imaging System for analysis

Assay Performance Characteristics


Sample Concentration (pg/ml) %CV
Sample 1 1571.82 5%
Sample 2 84.33 10%
Sample 3

Intra-assay (n=20)
Average Intra-assay CV: 8%

Sample Concentration (pg/ml) %CV
Sample 1 8533.89 9%
Sample 2 99.77 14%
Sample 3 34.23 12

Inter-assay (n=15)
Average Inter-assay CV: 12%

Dilutional Linearity

Dilution Factor % Recovery
Stripped Serum Cell Culture Supernatant Sample 3 Sample 4
2 82% 106% Not Detectable Not Detectable
4 86% 104%
8 88% 109%

Average percent linearity: 98%
Percent linearity range: 91 – 104%

Human TIMP-2 Linearity

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