Mouse IL-6 Analyte Overview

Mouse IL-6

Also known as Interleuken 6

Interleuken 6 (IL-6) has the capability to behave as both a pro-inflammatory cytokine and an anti-inflammation myokine. As a cytokine, it is secreted by macrophages in response to microbial activity, to  regulate the progression of fever through raising the temperature of muscle and fat, as well as crossing the blood-brain barrier to alter the body’s temperature set point in the hypothalamus. It acts through T cells and macrophages fighting infection and causing inflammation. As a myokine, it is released by contracting muscles during exercise, and inhibits the activity of pro-inflammatory agent TNF-alpha, reducing system-wide inflammation. In addition to its functions in the immune system, IL-6 aids in bone remodeling and maintenance by stimulating the production of osteoclasts. Clinically, IL-6 is implicated in the inflammatory and autoimmune symptoms of many diseases, including diabetes, asthma, atherosclerosis, depression, Alzheimer’s disease, rheumatoid arthritis, and many cancers. High levels of IL-6 are common in advanced cancer patients and are correlated with low survival rates. IL-6 has the ability to induce epigenetic modifications of gene transcription in the brain, and these IL-6 modifications are associated with schizophrenia and major depressive disorder.

Q-Plex™ Details

Species: Mouse
Assay Type: Sandwich
Sample Type: Serum/Plasma
Assay Range: 504 – 0.69 pg/mL
Lower Limit of Detection (LLD): 0.35 pg/mL
Volume Required Per Well: Min. 25µL
Detection Method: Chemiluminescent
Singleplex Format: 96-well plate

Features & Requirements

  • Measure IL-6 in 2.25 hours
  • Sensitive, reproducible, and convenient 96-well format requiring low sample volumes
  • Requires the Q-View™ Imaging System for analysis

Featured Q-Plex Products

Q-Plex™ Mouse Cytokine Inflammation HS (13-Plex)

GMCSF, IL-1α, IL-1β, IL-2, IL-3, IL-4, IL-6, IL-10, IL-12p70, IL-17A, MIP-1α, RANTES, TNFα

Q-Plex™ Mouse Cytokine Panel 1 HS (6-Plex)

IFNγ, IL-1α, IL-1β, IL-6, IL-10, TNF

Q-Plex™ Mouse Cytokine Panel 2 HS (4-Plex)

IFNγ, IL-1β, IL-6, TNFα

Q-Plex™ Mouse Cytokine Panel 3 HS (4-Plex)

IL-2, IL-4, IL-6, TNFα

Q-Plex™ Mouse Cytokine Screen HS (15-Plex)

GMCSF, IFNγ, IL-1α, IL-1β, IL-2, IL-3, IL-4, IL-5, IL-6, IL-10, IL-12p70, IL-17A, MIP-1α, RANTES, TNFα

Q-Plex™ Mouse Cytokine Screen HS Stripwells (15-Plex)

GMCSF, IFNγ, IL-1α, IL-1β, IL-2, IL-3, IL-4, IL-5, IL-6, IL-10, IL-12p70, IL-17A, MIP-1α, RANTES, TNFα

Not Finding What You Need?

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Not seeing the biomarker or analyte you need? Customize your kit! The Q-Plex™ Custom Assays are fully quantitative ELISA-based Chemiluminescent assay kits allowing the concurrent measurement of up to 18 biomarkers or analytes.

Send in Your Samples

Choose up to 18 different biomarkers that will work best for your research. Send in your samples and let us run them for you. 

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Have questions about the kit or interested in more information? Contact one of our representative to get all your questions answered. 

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