NHP CXCL-1 Analyte Overview
Also known as Chemokine Ligand 1, GROα, KC, CINC-1, Neutrophil-activating protein 3 (NAP-3), GRO1, Melanoma Growth Stimulating Activity alpha (MGSA-α)
CXCL-1 or GROα, is a proinflammatory chemokine that plays a role in immune responses and many cancers. In the healthy immune system, CXCL-1/GROα is produced by monocytes, epithelial cells, and fibroblasts in response to inflammatory activity. It induces neutrophil migration through chemotaxis and has antimicrobial effects. It is also capable of promoting lymphatic tube and blood vessel formation within the circulatory system. In individuals with chronic inflammatory diseases, it is produced at high levels by many cell types. Abnormally high levels of CXCL-1 stimulate the growth of tumors and are particularly associated with melanomas due to their normal expression in epithelial cells.
Typical Assay Characteristics
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