NHP IL-17a Analyte Overview

NHP IL-17a

Also known as Interleukin-17, IL-17a

Interleukin 17 (IL-17) are a small family of similarly structured cytokines that plays a role in pro-inflammatory responses of the immune system, particularly allergic reactions. Each variant of IL-17 appears to have slightly nuanced function in different organs, but on the whole the cytokines behave similarly. IL-17 induces inflammation by stimulating the secretion of pro-inflammatory molecules such as IL-6, IL-8, GM-CSF, IL-1, TNF-α, and MCP-1 from their respective cell types. For this reason, IL-17 is linked to inflammatory and autoimmune diseases such as rheumatoid arthritis, asthma, lupus, psoriasis, and multiple scelrosis. Overactivity of IL-17 is commonly found in severe cases of asthma and psoriasis, where it contributes to inflammation that damages the airway and skin, respectively. IL-17 suppression is under investigation as a clinical target for reducing symptoms of inflammatory diseases, improving recovery following stroke, and treatment of some types of cancer.

Typical Assay Characteristics

NHP IL-17a analyte graph
Precision Linearity
Inter-assay Intra-assay Range Average
19% 13% 110%-121% 117%

Q-Plex™ Details

Species: NHP
Assay Type: Sandwich
Sample Type: Serum/Plasma, Cell Supernatant
Assay Range: 5,589 – 7.67 pg/mL
Lower Limit of Detection (LLD): 3.83 pg/mL
Volume Required Per Well: Min. 25µL
Detection Method: Chemiluminescent
Singleplex Format: 96-well plate

Features & Requirements

  • Data available as fast as 4 hours
  • Sensitive, reproducible, and convenient 96-well format requiring low sample volumes
  • Requires the Q-View™ Imaging System for analysis of multiplexed chemiluminescent planar-based arrays

Featured Q-Plex Products

Q-Plex™ NHP Cytokine Screen (16-Plex)

CXCL-1, GMCSF, IFNγ, IL-1ß, IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12p70, IL-13, IL-15, IL-17A, IL-18, TNFα

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