NHP IL-18 Analyte Overview
Also known as interferon gamma inducing factor
Interleukin 18 (IL-18) is a member of the IL-1 family of cytokines most known for its ability to stimulate production of IFNγ from T cells and natural killer (NK) cells in conjunction with IL-12. It is mainly produced by macrophages after stimulation with LPS but several cell types are capable of its production. Although initially described as an IFNγ promoting factor IL-18 has since been shown to act on non-polarized T cells, NK cells, B cells, dendritic cells, and macrophages to product IFNγ while in the presence of IL-12. IL-18 without IL-12 but in the presence of IL-2 has been shown to induce Th2 cytokine production in T cells. Additionally, IL-18 with Il-3 induces mast cells and basophils to product IL-4 and IL-13 showing that IL-18 can act on both the adaptive and innate immune systems.
Typical Assay Characteristics
Features & Requirements
- Data available as fast as 4 hours
- Sensitive, reproducible, and convenient 96-well format requiring low sample volumes
- Requires the Q-View™ Imaging System for analysis of multiplexed chemiluminescent planar-based arrays
Not Finding What You Need?
Customize a Kit
Not seeing the biomarker or analyte you need? Customize your kit! The Q-Plex™ Custom Assays are fully quantitative ELISA-based Chemiluminescent assay kits allowing the concurrent measurement of up to 18 biomarkers or analytes.
Send in Your Samples
Choose up to 18 different biomarkers that will work best for your research. Send in your samples and let us run them for you.
Contact a Representative
Have questions about the kit or interested in more information? Contact one of our representative to get all your questions answered.
As researchers and problem solvers ourselves, we understand the value of sound data. We are proud to be a part of research that can better the world. We value the relationships, partnerships, and friendships that we have built with the people who trust and use our technology. We are committed to building these relationships. You can count on us to answer the phone and take time to thoroughly address questions or concerns about any of our products. In an industry that is reputed for grandiose claims, we trust that our quality standards and our customer service set us apart from the competition. If you’re happy with our products or if you think we can do something better, we hope you will let us know.