NHP IL-18 Analyte Overview
Also known as interleukin 18, interferon gamma inducing factor
Interleukin 18 (IL-18) is a member of the IL-1 family of cytokines most known for its ability to stimulate production of IFNγ from T cells and natural killer (NK) cells in conjunction with IL-12. It is mainly produced by macrophages after stimulation with LPS but several cell types are capable of its production. Although initially described as an IFNγ promoting factor IL-18 has since been shown to act on non-polarized T cells, NK cells, B cells, dendritic cells, and macrophages to product IFNγ while in the presence of IL-12. IL-18 without IL-12 but in the presence of IL-2 has been shown to induce Th2 cytokine production in T cells. Additionally, IL-18 with Il-3 induces mast cells and basophils to product IL-4 and IL-13 showing that IL-18 can act on both the adaptive and innate immune systems.
Typical Assay Characteristics
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