NHP IL-5 Analyte Overview
Also known as Interleukin 5, Eosinophil differentiation factor, TRF, BCDF, B-cell differentiation factor I, Eo-CSF
Interleukin 5 (IL-5) is a cytokine that modules immune system activities. It is secreted by activated TH2 cells, mast cells, eosinophils, EBV-transformed B cells, Reed-Sternberg cells (found in Hodgkin’s Disease) and iNKT cells. It increases immunoglobulin secretion, stimulates B-cell growth, and promotes eosinophilic and basophilic white blood cell differentiation and activation, as well as increasing mobilization of eosinophils from bone marrow. In a healthy person, IL-5 supports immune responses to multicellular parasites through eosinophil proliferation. IL-5 is implicated in diseases that are characterized by high levels of eosinophils, particularly severe allergic diseases, such as hay fever and asthma.
Typical Assay Characteristics
Features & Requirements
- Data available as fast as 4 hours
- Sensitive, reproducible, and convenient 96-well format requiring low sample volumes
- Requires the Q-View™ Imaging System for analysis of multiplexed chemiluminescent planar-based arrays
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