Human IL-15 Analyte Overview

Human IL-15

Also known as Interleukin-15

Interleukin 15 (IL-15) is a common cytokine that is similar to IL-2 structurally and functionally and plays an important role in the innate immune system. IL-15 stimulates the proliferation of T-lymphocytes and natural killer cells, and assists in their maintenance, activation, and differentiation. Research on Interleukin 15 and its receptor complex indicate involvement in processes such as aging, cell maturation, and regulation of cellular processes. Overexpression of IL-15 is associated with pediatric asthma, Celiac disease, and non-alcoholic fatty liver disease, and anti-IL-15 therapeutics are under investigation for the treatment of these conditions. In cancer biology, IL-15 displays anti-tumor properties and is being reviewed as a component of both anti-viral and anti-tumor vaccines. IL-15 is a target of particular interest for patients with both HIV infection and cancer, as it appears to support improved both tumor reduction and improved immune function.

IL-15 Q-Plex™ details

Species: Human
Assay Type: Sandwich
Sample Type: Human Serum, EDTA Plasma
Assay Range: 10,733 – 14.74 pg/ml
Lower Limit of Detection (LLD): 6.87 pg/ml
Volume Required Per Well: Min 25µl
Detection Method: Chemiluminescent
Singleplex Format: 96-well plate
Catalog No: 465149HU

N

Measure IL-15 in 2.25 hours

N

Sensitive, reproducible, and convenient 96-well format requiring low sample volumes

N

Requires the Q-View™ Imaging System for analysis

IL-13 Assay Performance Characteristics

Precision

Intra-assay (n=20)
Average Intra-assay CV: 10%

Sample Concentration (pg/ml) %CV
Sample 1

185.78

8%
Sample 2 10.37 12%
Sample 3 240.61 9%

 

Inter-assay (n=15)
Average Inter-assay CV: 10%

Sample Concentration (pg/ml) %CV
Sample 1 12.84 10%
Sample 2 251.93 11%
Sample 3 12.10 10%

 

Dilutional Linearity

Average percent linearity: 101%
Percent linearity range: 88 – 114%

Dilution Factor % Recovery
EDTA Plasma Heparin Plasma Serum Cell Culture Supernate
2 88% 103% 93% 109%
4 99% 94% 100% 114%
8 99% 104% 102% 101%
Human il-15 linearity

Q-Plex Multiplexed Products featuring IL-15

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