fbpx

Human IP-10 Analyte Overview

Human IP-10

Also known as Interferon Gamma-Induced Protein 10, CXCL10, C-X-C Motif Chemokine 10

Interferon gamma-induced protein 10 (IP-10), also known as C-X-C motif chemokine 10 (CXCL10) or small-inducible cytokine B10, is a small cytokine with diverse roles in the immune system. Many cell types release IP-10 in response to stimulation from IFN-γ. It has chemotactic properties for activated T cells, monocytes, macrophages, natural killer cells, and dendritic cells. It promotes the adhesion of T cells to endothelial cells and has strong anti-tumor properties. It inhibits bone marrow colony formation and angiogenesis. IP-10 expression has been associated with HIV-1 infection, where it contributes to the accumulation of activated T cells in the cerebrospinal fluid compartment of infected individuals. The retroviral transactivator, HIV-1 Tat, is a potent inducer of IP-10 expression in astrocytes. IP-10 expression has also been shown to be significantly elevated in astrocytes within the brains of Alzheimer’s disease patients, where its expression is associated with senile plaques. Higher levels of IP-10 are documented in Hepatitis C patients who respond poorly to antiviral treatment.

Q-Plex™ Details

Species: Human
Assay Type: Sandwich
Sample Type: Human Serum, EDTA Plasma
Assay Range: 2,984 – 4.10 pg/mL
Lower Limit of Detection (LLD): 4.03 pg/mL
Volume Required Per Well: Min. 25µL
Detection Method: Chemiluminescent
Singleplex Format: 96-well plate
Catalog #: 466849HU

Features & Requirements

  • Measure IP-10 in 2.25 hours
  • Sensitive, reproducible, and convenient 96-well format requiring low sample volumes
  • Requires the Q-View™ Imaging System for analysis

Assay Performance Characteristics

Precision

Intra-assay (n=20)
Average Intra-assay CV: 5%

Sample Concentration (pg/ml) %CV
Sample 1

770.42

6%
Sample 2 50.73 5%
Sample 3 16.40 4%

 

Inter-assay (n=15)
Average Inter-assay CV: 6%

Sample Concentration (pg/ml) %CV
Sample 1 146.35 3%
Sample 2 172.85 8%
Sample 3 243.14 9%

 

Dilutional Linearity

Average percent linearity: 100%
Percent linearity range: 88 – 119%

Dilution Factor % Recovery
Activated Plasma Pooled Plasma Serum HE Cell Culture Supernatant
2 110% 104% 119% 107%
4 98% 96% 88% 98%
8 102% 98% 89% 93%
human IP-10 linearity

Featured Q-Plex Products

Human Multiplex Kits

Not Finding What You Need?

Customize a Kit

Not seeing the biomarker or analyte you need? Customize your kit! The Q-Plex™ Custom Assays are fully quantitative ELISA-based Chemiluminescent assay kits allowing the concurrent measurement of up to 18 biomarkers or analytes.

Send in Your Samples

Choose up to 18 different biomarkers that will work best for your research. Send in your samples and let us run them for you. 

Contact a Representative

Have questions about the kit or interested in more information? Contact one of our representative to get all your questions answered. 

As researchers and problem solvers ourselves, we understand the value of sound data. We are proud to be a part of research that can better the world. We value the relationships, partnerships, and friendships that we have built with the people who trust and use our technology. We are committed to building these relationships. You can count on us to answer the phone and take time to thoroughly address questions or concerns about any of our products. In an industry that is reputed for grandiose claims, we trust that our quality standards and our customer service set us apart from the competition. If you’re happy with our products or if you think we can do something better, we hope you will let us know.