Human TIMP-2 Analyte Overview

Human TIMP-2

Also known as Tissue inhibitor of metalloproteinases 2

Tissue inhibitor of metalloproteinases 2 (TIMP2) is a glycoprotein in the TIMP family of proteins, which regulate the activity of matrix metalloproteinases. Metalloproteinases degrade the extracellular matrix. As an inhibitor of metalloproteinases, TIMP2 minimizes matrix digestion by these enzymes and is most effective at inhibiting MMP2. TIMP2 also has the unique ability to repress the proliferation of endothelial cells. It may be critical to tissue homeostasis, preventing the overgrowth of certain cell types during blood vessel formation and limiting MMP2 activity in the extracellular matrix of tissues during remodeling. TIMP2 is critical to normal hippocampal behavior and supports cognitive function. It may suppress certain cancers by preventing cell proliferation during angiogenesis.

TIMP-2 Q-Plex™ details

Species: Human
Assay Type: Sandwich
Sample Type: Human Serum, EDTA Plasma
Assay Range: 20,000 – 27.40 pg/ml
Lower Limit of Detection (LLD): 15.90 pg/ml
Volume Required Per Well: Min 25µl
Detection Method: Chemiluminescent
Singleplex Format: 96-well plate
Catalog No: 469649HU


Measure TIMP-2 in 2.25 hours


Sensitive, reproducible, and convenient 96-well format requiring low sample volumes


Requires the Q-View™ Imaging System for analysis

TIMP-2 Assay Performance Characteristics


Intra-assay (n=20)
Average Intra-assay CV: 8%

Sample Concentration (pg/ml) %CV
Sample 1


Sample 2 84.33 10%
Sample 3


Inter-assay (n=15)
Average Inter-assay CV: 12%

Sample Concentration (pg/ml) %CV
Sample 1 8533.89 9%
Sample 2 99.77 14%
Sample 3 34.23 12


Dilutional Linearity

Average percent linearity: 98%
Percent linearity range: 91 – 104%

Dilution Factor % Recovery
Stripped Serum Cell Culture Supernatant Sample 3 Sample 4
2 82% 106% Not Detectable Not Detectable
4 86% 104%    
8 88% 109%    
Human TIMP-2 Linearity

Q-Plex Multiplexed Products featuring TIMP-2

Q-Plex Products featuring TIMP-2

Human Multiplex Kits

Human Angiogenesis (9-plex)

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